Inadvertent exposure of corneal endothelium to 5-fluorouracil
نویسندگان
چکیده
منابع مشابه
Fabrication and Optimization of Molecularly Imprinted Nanofibers in Assessment of Occupational Exposure to 5-fluorouracil
Background and purpose: Cytotoxic drugs are a group of chemicals that raise concerns over the health of healthcare professionals. Therefore, accurate methods are needed to investigate the traces of these drugs. This study was done to fabricate and optimize molecularly imprinted membrane as a specific absorbent in assessment of occupational exposure to 5-fluorouracil. Materials and methods: 5-F...
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The endothelial surface of the isolated rabbit cornea was perfused with modified KEI medium, according to the method reported previously. This in vitro cornea maintained its thickness within the normal range even after the epithelium ivas removed. The endothelial permeability of these in vitro corneas to tritiated water, >C-labeled urea, sucrose, and inulin teas determined. The reflection coeff...
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Treatment with 5-fluorouracil is common in oncological patients. Side effects on bone marrow, skin, and mucous membranes have been reported. Cardiotoxicity, which is less predictable, can be life-threatening. Manifestations include angina, arrhythmias, infarction, heart failure and cardiogenic shock. The toxic mechanisms that might be involved have been much discussed but have not yet been clea...
متن کاملPostnatal development of corneal endothelium.
Comparison specular micrographs of infant and adult corneas from cats, cows, dogs, rabbits, and humans demonstrate that a large decrease in central endothelial cell density occurs during maturation of the cornea. Central endothelial cell counts of developing cat, dog, and rabbit corneas decrease rapidly during the first months of life. This rapid decline in endothelial cell density correlates w...
متن کاملPathology of the corneal endothelium.
Clinical specular microscopy has indicated that human cell healing occurs by spreading, there is a limited healing reserve, and premature cell loss is the equivalent of a "premature aging" that may lead to later decompensation. This instrument has been useful in studying healing and cell damage from surgery, drugs, and special procedures such as intraocular lens insertion. It pointed out extens...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 1999
ISSN: 0007-1161
DOI: 10.1136/bjo.83.3.373d